Emerging neuroscience indicates that the experience of chronic pain relates more to nervous system sensitisation than structural change in the body. Traditional biomedical treatments such as medications and procedures are generally ineffective in reducing nervous system sensitisation and pain. Active self-management strategies have greater effectiveness. Neuroscience education, mindbody awareness, social connection, physical activity and nutrition play key roles in gradual pain reduction over time. This presentation will review relevant scientific evidence and recommend practical management approaches. The recent launch of novel educational videos via social media will be highlighted.